Summary Characteristics for All Volunteers Completing Study Procedures with Evaluable Data
| Parameter | Before endotoxin | 16 h after endotoxin | Most abnormal value after endotoxin | P |
| Age (y) | 35 ± 6 | N/A | N/A | N/A |
| Sex | 3 women, 4 men | N/A | N/A | N/A |
| Race/ethnicity | 3 Caucasian/4 African-American | N/A | N/A | N/A |
| Vital signs* | ||||
| Temperature (ºC) | 36.5 ± 0.3 | 36.3 ± 0.4 | 37.3 ± 0.3 (highest) | 0.0016† |
| Heart rate (beats/min) | 69 ± 11 | 72 ± 11 | 92 ± 9 (highest) | 0.0015† |
| 60 ± 6 (lowest) | 0.0208 | |||
| Blood pressure, systolic/diastolic (mm Hg) | 116 ± 6/69 ± 5 | 113 ± 6/72 ± 5 | 100 ± 13/50 ± 6 (lowest) | 0.0071/0.016 |
| Mean arterial pressure | 85 ± 5 | 85 ± 5 | 69 ± 7 (lowest) | 0.0000† |
| SaO2 (% on room air) | 99 ± 1 | 99 ± 1 | 95 ± 2 (lowest) | 0.016 |
| Respiratory rate (breaths/min) | 17 ± 1 | 18 ± 2 | 22 ± 2 (highest) | 0.0002† |
| Pulmonary function tests | ||||
| FEV1 (L) | 3.7 ± 0.7 | 3.6 ± 0.6 | N/A | 0.424 |
| % predicted FEV1 | 108 ± 12 | 106 ± 16 | N/A | 0.548 |
| FVC (L) | 4.5 ± 1.0 | 4.5 ± 0.9 | N/A | 0.824 |
| % predicted FVC | 108 ± 10 | 109 ± 15 | N/A | 0.888 |
| Complete blood count | ||||
| White blood cells (×103/μL) | 6.6 ± 1.4 | 10.8 ± 2.4† | N/A | 0.0026† |
| % neutrophils | 62 ± 5 | 73 ± 7† | N/A | 0.0069 |
| Hemoglobin (g/dL) | 14 ± 2 | 13 ± 2 | N/A | 0.16 |
| Hematocrit (%) | 41 ± 5 | 38 ± 6 | N/A | 0.183 |
| Platelets (×103/μL) | 274 ± 59 | 254 ± 38 | N/A | 0.247 |
| ESR (mm/h) | 20 ± 18 | 18 ± 14 | N/A | 0.337 |
| Change in ESR | N/A | −2.4 ± 6.2 | N/A | |
| CRP (mg/dL) | 9 ± 15 | 14 ± 19 | N/A | 0.016 |
| Change in CRP | N/A | 5.1 ± 3.6 | N/A |
↵* Statistical testing for vital signs was performed only on the most abnormal value after endotoxin instillation.
↵† P < 0.0026 (significance level with Bonferroni adjustment).
N/A = not applicable; FEV1 = forced expiratory volume in 1 s; FVC = forced vital capacity; ESR = erythrocyte sedimentation rate; CRP = C-reactive protein.