TABLE 2

Tissue Distribution of CRL-3–^99mTc After Subcutaneous Injection of Mice with HEK 293 Cells Expressing CCK2R

	Tissue distribution at:
Organ	0.5 h	2 h	4 h	8 h	24 h
Blood	5.8 ± 2.7	1.9 ± 0.97	1.7 ± 0.39	0.24 ± 0.19	0.10 ± 0.06
Skin	2.3 ± 1.2	1.0 ± 0.41	1.1 ± 0.23	0.42 ± 0.22	0.21 ± 0.13
Spleen	2.1 ± 1.2	0.69 ± 0.70	1.4 ± 0.41	0.65 ± 0.42	0.45 ± 0.39
Pancreas	1.3 ± 0.62	0.69 ± 0.84	0.29 ± 0.19	0.10 ± 0.06	0.053 ± 0.03
Small intestine	1.2 ± 0.63	0.52 ± 0.28	0.52 ± 0.08	0.19 ± 0.10	0.13 ± 0.08
Large intestine	1.0 ± 0.52	0.46 ± 0.20	0.53 ± 0.11	0.24 ± 0.16	0.13 ± 0.08
Stomach	1.2 ± 0.61	0.58 ± 0.32	0.56 ± 0.16	0.24 ± 0.15	0.15 ± 0.09
Liver	6.7 ± 3.6	2.5 ± 2.4	4.1 ± 0.64	1.9 ± 1.2	1.4 ± 1.4
Left kidney	11.2 ± 6.1	8.4 ± 4.6	13.4 ± 2.1	6.0 ± 3.1	2.6 ± 1.6
Right kidney	11.4 ± 6.3	7.6 ± 4.4	12.8 ± 1.8	5.7 ± 3.0	2.6 ± 1.7
Heart	2.3 ± 1.5	0.68 ± 0.47	0.59 ± 0.18	0.14 ± 0.078	0.076 ± 0.05
Lungs	3.2 ± 1.7	1.2 ± 0.55	1.0 ± 0.23	0.29 ± 0.15	0.18 ± 0.12
Muscle	0.8 ± 0.4	0.29 ± 0.096	0.3 ± 0.04	0.093 ± 0.048	0.070 ± 0.08
Brain	0.13 ± 0.07	0.051 ± 0.02	0.053 ± 0.016	0.064 ± 0.12	0.0076 ± 0.005
Tumor	7.4 ± 4.6	8.1 ± 5.1	12.0 ± 2.0	8.5 ± 4.9	6.3 ± 3.7

Uptake of radioactivity is expressed as percentage injected dose per gram of wet tissue (n = 5 at 0.5, 4, 8, and 24 h; n = 10 at 2 h).