TABLE 3

P Values of Prognostic Factors in Multivariate Analysis Regarding OS

Parameter	P	HR	95% CI
Age (≥55 vs. <55 y)	0.015	1.82	1.12–2.94
MGMT promoter methylation (no vs. yes)	<0.001	2.78	1.71–4.50
TTP_min (≤12.5 min vs. >12.5 min)	0.009	2.04	1.20–3.48
Age (≥55 vs. <55 y)	0.007	1.95	1.02–3.17
MGMT promoter methylation (no vs. yes)	<0.001	2.73	1.70–4.39
WHO (IV vs. III)	0.042	1.73	1.02–2.93
Age (≥55 vs. <55 y)	0.026	1.73	1.07–2.68
MGMT promoter methylation (no vs. yes)	<0.001	2.62	1.61–4.27
WHO (IV vs. III)	0.150	1.49	0.87–2.56
TTP_min (≤12.5 min vs. >12.5 min)	0.023	1.89	1.09–3.22

HR = hazard ratio; CI = confidence interval.
P values were derived from multivariate Cox regression.
The two alternative models, excluding either WHO grade or TTP_min as a factor, reached a similar fit. In the model with both factors, TTP_min remains significant.