Subject Demographics
Parameter | Control (n = 30) | AD (n = 38) | DLB (n = 30) | Test |
Age (y) | 76.3 ± 6.6 | 75.8 ± 7.5 | 76.5 ± 5.8 | F2,95 = 0.09, P = 0.9 |
Education (y) | 11.9 ± 2.8 | 11.5 ± 2.6 | 10.6 ± 2.3 | F2,95 = 1.91, P = 0.15 |
Sex | χ2 = 2.6, P = 0.27 | |||
Female | 10 | 16 | 7 | |
Male | 20 | 22 | 23 | |
Duration of dementia (mo) | — | 44.0 ± 22.9 (12–132) | 38.1 ± 27.3 (9–120) | t66 = 0.99, P = 0.3* |
Mini-Mental Status Examination | 28.9 ± 1.1 (26–30) | 20.9 ± 3.7 (15–28) | 21.8 ± 4.2 (14–28) | t66 = −1.0, P = 0.3* |
Cambridge Cognitive Examination | 98.4 ± 4.0 | 71.3 ± 11.6 | 72.6 ± 13.1 | t66 = −0.43, P = 0.7* |
Rey total | 70.3 ± 12.3 | 25.6 ± 10.0 | 33.4 ± 12.1 | t66 = −2.9, P = 0.005* |
Cornell | 1.8 ± 1.8 | 4.5 ± 2.7 | 8.1 ± 3.8 | F2,95 = 36.2, P < 0.001 |
Clinician Assessment of Fluctuation scale total | — | 1.5 ± 2.5 | 6.0 ± 4.7 | t65 = −4.7, P < 0.001* |
Neuropsychiatric Index total | — | 15.6 ± 15.4 | 19.7 ± 15.6 | t65 = −1.1, P = 0.3* |
UPDRS† | 2.6 ± 2.7 | 3.6 ± 3.2 | 25.5 ± 11.9 | F2,95 = 105, P < 0.001 |
↵* AD vs. DLB Student t test.
↵† Motor part of UPDRS.
Values are mean ± SD, with range in parentheses. ANOVA Tukey post hoc tests: UPDRS = control vs. AD post hoc P = 0.8, DLB > AD and DLB > control P < 0.001. Cornell = control < AD < DLB P = 0.001. There were data only for 29 DLB for Clinician Assessment of Fluctuation scale and Neuropsychiatric Index scores.