TABLE 2

Biodistribution Comparison Among Peptides in B16/F1 Melanoma–Bearing C57 Mice 2 Hours After Injection

Tissue	GGG	GSG	PEG₂	Aoc
%ID/g
Tumor	9.78 ± 3.40	7.41 ± 4.26	14.32 ± 2.82	22.3 ± 1.72
Brain	0.05 ± 0.03	0.07 ± 0.11	0.03 ± 0.02	0.04 ± 0.04
Blood	0.07 ± 0.01	0.08 ± 0.06	0.39 ± 0.07	0.28 ± 0.01
Heart	0.04 ± 0.03	0.06 ± 0.02	0.08 ± 0.03	0.20 ± 0.10
Lung	0.18 ± 0.12	0.15 ± 0.05	0.27 ± 0.12	0.38 ± 0.19
Liver	0.26 ± 0.03	0.23 ± 0.01	0.33 ± 0.03	0.81 ± 0.03
Spleen	0.16 ± 0.09	0.08 ± 0.02	0.11 ± 0.08	0.24 ± 0.00
Stomach	0.43 ± 0.27	0.48 ± 0.39	0.43 ± 0.05	0.70 ± 0.36
Kidneys	5.09 ± 2.19	3.90 ± 1.01	5.79 ± 1.79	6.52 ± 1.04
Muscle	0.03 ± 0.03	0.05 ± 0.02	0.03 ± 0.01	0.06 ± 0.05
Pancreas	0.02 ± 0.01	0.02 ± 0.02	0.08 ± 0.06	0.09 ± 0.00
Bone	0.08 ± 0.06	0.12 ± 0.13	0.29 ± 0.14	0.27 ± 0.10
Skin	0.31 ± 0.10	0.22 ± 0.06	0.49 ± 0.07	0.43 ± 0.11
%ID
Intestines	0.52 ± 0.09	0.72 ± 0.27	0.99 ± 0.55	1.85 ± 0.51
Urine	93.90 ± 1.47	95.25 ± 0.52	93.19 ± 1.91	88.46 ± 2.23
T/NT
Liver	37.26	32.26	43.14	27.51
Kidney	1.92	1.90	2.48	3.42
Lung	54.44	50.07	53.72	57.99
Muscle	351.42	146.90	465.25	378.94
Blood	147.62	98.05	36.80	79.79
Skin	31.75	34.01	29.40	52.23

GGG = ^99mTc(EDDA)-HYNIC-GGGNle-CycMSH_hex; GSG = ^99mTc(EDDA)-HYNIC-GSGNle-CycMSH_hex; PEG₂ = ^99mTc(EDDA)-HYNIC-PEG₂Nle-CycMSH_hex; Aoc = ^99mTc(EDDA)-HYNIC-AocNle-CycMSH_hex; T/NT = tumor–to–normal-tissue uptake ratio.
Data are %ID/g or %ID (mean ± SD, n = 5).