TABLE 1

Design of Repeated-Dose Study in AR42J Tumor Mice

Group	No. of animals per group	No. of doses	Treatment	Route	End time
1	10	6	Decayed generator eluate	Intravenous	16 d
2	10	6	530 ng of nonradiolabeled P2045	Intravenous	16 d
3	10	6	1.85 MBq of ¹⁸⁸Re-P2045	Intravenous	16 d
4	10	6	5.55 MBq of ¹⁸⁸Re-P2045	Intravenous	16 d
5	10	6	11.1 MBq of ¹⁸⁸Re-P2045	Intravenous	28 d
6	7	1	22.2 MBq of ⁸⁸Y-DOTATOC	Intraperitoneal	16 d
7	5	1	9.25 MBq of ¹⁸⁸Re-P2045	Intravenous	4 h
8	5	1	9.25 MBq of ¹⁸⁸Re-P2045	Intravenous	24 h
9	5	1	11.1 MBq of ⁸⁸Y-DOTATOC	Intravenous	4 h
10	5	1	11.1 MBq of ⁸⁸Y-DOTATOC	Intravenous	24 h