Biodistribution of 64Cu-CB-TE1A1P-PEG4-LLP2A and 64Cu-NODAGA-PEG4-LLP2A in B16F10 Tumor–Bearing Mice
| Organs | 64Cu-NODAGA (2 h) | 64Cu-NODAGA (2-h block) | 64Cu-NODAGA (4 h) | 64Cu-CB-TE1A1P (2 h) | 64Cu-CB-TE1A1P (2-h block) | 64Cu-CB-TE1A1P (4 h) |
| Tumor | 14.0 ± 3.8 | 2.2 ± 0.7 | 13.4 ± 1.7 | 15.1 ± 1.0 | 0.9 ± 0.2 | 16.9 ± 2.2 |
| Thymus | 7.4 ± 2.6 | 0.6 ± 0.4 | 8.1 ± 1.2 | 6.5 ± 1.3 | 0.4 ± 0.1 | 7.1 ± 0.7 |
| Blood | 1.1 ± 0.5 | 0.6 ± 0.4 | 0.7 ± 0.2 | 1.2 ± 0.6 | 0.4 ± 0.3 | 0.4 ± 0.1 |
| Heart | 0.9 ± 0.1 | 0.9 ± 0.3 | 0.8 ± 0.1 | 0.6 ± 0.1 | 0.3 ± 0.1 | 0.4 ± 0.1 |
| Lung | 6.2 ± 0.7 | 3.6 ± 0.9 | 4.7 ± 0.6 | 4.6 ± 0.2 | 0.7 ± 0.2 | 3.9 ± 0.5 |
| Liver | 5.4 ± 0.6 | 6.8 ± 1.2 | 4.8 ± 0.3 | 3.0 ± 0.2 | 1.7 ± 0.3 | 2.4 ± 0.1 |
| Kidney | 5.6 ± 0.9 | 6.5 ± 1.7 | 4.3 ± 0.5 | 2.9 ± 0.2 | 2.9 ± 0.3 | 2.8 ± 0.5 |
| Spleen | 23.9 ± 4.8 | 0.7 ± 0.5 | 15.6 ± 5.1 | 18.1 ± 1.3 | 0.3 ± 0.1 | 15.3 ± 2.1 |
| Muscle | 1.0 ± 0.3 | 0.2 ± 0.2 | 0.7 ± 0.1 | 1.3 ± 0.8 | 0.2 ± 0.1 | 0.8 ± 0.3 |
| Bone | 6.1 ± 1.8 | 0.8 ± 0.5 | 3.9 ± 0.1 | 7.9 ± 1.9 | 0.9 ± 0.5 | 7.7 ± 1.2 |
| Small intestine | 5.2 ± 1.8 | 6.7 ± 2.7 | 4.3 ± 1.5 | 2.6 ± 1.0 | 0.9 ± 0.5 | 2.1 ± 0.2 |
| Large intestine | 4.3 ± 3.1 | 2.7 ± 0.9 | 7.9 ± 1.1 | 1.4 ± 0.3 | 0.3 ± 0.1 | 1.2 ± 0.7 |
n = 4; values are expressed as mean ± SD.