Global Physiologic Variables at Baseline (After Unilateral Lung Lavage) and After 4 Hours of Mechanical Ventilation
| LPS− | LPS+ | P | ||||
| Variable | Baseline (n = 6) | 4 h (n = 6) | Baseline (n = 6) | 4 h (n = 6) | Time | LPS |
| VT (mL/kg) | 15.7 ± 5.6 | 16.6 ± 4.7 | 13.4 ± 3.5 | 11.8 ± 2.7 | 0.63 | 0.16 |
| PEEP (cm H2O) | 10 (10–11) | 10 (9–11) | 9 (8–10) | 9 (8–10) | 0.73 | 0.18 |
| Respiratory rate (/min) | 23 ± 4 | 23 ± 4 | 21 ± 5 | 21 ± 4 | 0.66 | 0.33 |
| PaO2/FiO2 (torr) | 149 (102–320) | 161 (123–173) | 109 (84–300) | 89 (64–211) | 0.92 | 0.37 |
| PaCO2 (torr) | 33 ± 5 | 37 ± 7 | 36 ± 10 | 39 ± 4 | 0.20 | 0.38 |
| Crs (mL/cm H2O) | 17.4 ± 6.3 | 18.6 ± 4.1 | 13.3 ± 3.5 | 11.2 ± 3.1* | 0.65 | 0.03 |
| Qs/Qt | 0.32 (0.18–0.48) | 0.35 (0.11–0.56) | 0.43 (0.23–0.53) | 0.56 (0.23–0.66) | 0.28 | 0.26 |
| PVR (dynes⋅s⋅cm−5) | 393 ± 99 | 314 ± 84 | 253 ± 82† | 584 ± 163‡ | <0.001 | 0.07 |
| MPAP (mm Hg) | 22 ± 2 | 22 ± 4 | 22 ± 5† | 34 ± 5‡ | <0.001 | 0.02 |
| MAP (mm Hg) | 102 ± 12 | 98 ± 18 | 84 ± 8 | 84 ± 23 | 0.77 | 0.04 |
| Heart rate (bpm) | 155 ± 43 | 157 ± 41 | 185 ± 29 | 167 ± 29 | 0.54 | 0.26 |
| Cardiac output (L/min) | 4.1 ± 1.3 | 3.3 ± 0.5 | 4.7 ± 0.8 | 3.7 ± 0.7 | 0.02 | 0.24 |
↵* P < 0.05 vs. LPS− group at 4 h of mechanical ventilation and LPS (mechanical ventilation + LPS).
↵† P < 0.001 vs. 4 h of mechanical ventilation + LPS for same group.
↵‡ P < 0.001 vs. LPS− group at 4 h of mechanical ventilation and LPS (mechanical ventilation + LPS).
VT = tidal volume; PEEP = positive end-expiratory pressure; Crs = respiratory system compliance; Qs/Qt = global shunt fraction; PVR = pulmonary vascular resistances; MPAP = mean pulmonary arterial pressure; MAP = mean arterial pressure.
Data are mean ± SD or median, with IQ (25-75) in parentheses.