99mTc-MIP-1404 | 99mTc-MIP-1405 | |||
Pharmacokinetic parameter | Healthy subject | Patient | Healthy subject | Patient |
Tmax (h) | 0.04 ± 0.02 | 0.03 ± 0.00 | 0.06 ± 0.03 | 0.05 ± 0.03 |
Cmax (h) | 0.72 ± 0.36 | 0.87 ± 0.33 | 0.58 ± 0.24 | 0.60 ± 0.15 |
AUC(0-∞) (h × 37 KBq [μCi]/mL) | 0.95 ± 0.32 | 1.34 ± 0.59 | 1.37 ± 0.51 | 1.44 ± 0.49 |
Clearance (mL/h/kg) | 283 ± 100 | 198 ± 70 | 200 ± 45 | 181 ± 104 |
Vss (mL/kg) | 4,020 ± 1,499 | 3,356 ± 1,371 | 938 ± 216* | 824 ± 602* |
T1/2 elimination (h) | 13.53 ± 2.18 | 15.26 ± 1.83 | 5.68 ± 0.97* | 5.12 ± 0.84* |
MRT(0-∞) (h) | 14.29 ± 3.29 | 16.95 ± 3.03 | 4.79 ± 1.06* | 4.31 ± 0.67* |
T1/2α (h) | 0.250 ± 2.5 | 0.12 ± 0.03 | 0.42 ± 0.30 | 0.21 ± 0.09 |
T1/2β (h) | 13.2 ± 2.79 | 13.87 ± 1.37 | 5.51 ± 0.79* | 5.03 ± 0.81* |
↵* These values for 99mTc-MIP-1405 are statistically (P < 0.05) significant, compared with values obtained for 99mTc-MIP-1404.
Cmax = maximum concentration in plasma; AUC(0-∞) = area under the curve; Vss = steady-state volume of distribution; MRT(0-∞) = mean residence time; T1/2α = distribution half-life; T1/2β = elimination half-life.