NSCLC: 10 Patients
Patient no. | Lesion type | 18F-FDG initial result | 18F-FDG T/BP | 18F-FMT initial result | 18F-FMT T/BP | Lesion size (cm) | Confirmation | 18F-FDG final result | 18F-FMT final result | 18F-FDG accuracy | 18F-FMT accuracy |
1 | Primary tumor (AC) | + | 1.5 | ++ | 2.1 | 2 | Histopathology | TP | TP | Understaged: N1 | Correct |
Lymph node, hilar ipsilateral | + | 1.1 | + | 1.7 | 0.8 | Histopathology | TP | TP | |||
Lymph node, mediastinal ipsilateral | − | − | + | 1.6 | 1.2 | Histopathology | FN | TP | |||
Lymph node, mediastinal ipsilateral | − | − | + | 1.5 | 1.2 | Histopathology | FN | TP | |||
2 | Primary tumor (AC) | + | 1.7 | − | 0.6 | 1.5 | Histopathology | TP | FN | Overstaged: (M1) | Understaged: (N0) |
Lymph node, hilar ipsilateral | + | 2.1 | − | − | 1 | Histopathology | TP | FN | |||
Lymph node, mediastinal ipsilateral | + | 1.7 | − | − | 0.8 | Histopathology | TP | FN | |||
Bone lesion (lumbar spine) | + | 1.3 | − | − | 1.2 | MR imaging, spine | FP | TN | |||
3 | Primary tumor (SCC) | ++ | 5.9 | + | 1.6 | 4.5 | Histopathology | TP | TP | Correct | Correct |
4 | Primary tumor (AC) | ++ | 6.4 | + | 1.4 | 5.7 | Histopathology | TP | TP | Correct | Correct |
5 | Primary tumor (SCC) | ++ | 7.3 | ++ | 3.2 | 6 | Histopathology | TP | TP | Overstaged: N3 | Correct |
Lymph node, mediastinal ipsilateral | ++ | 3.1 | + | 1.5 | 1.7 | Histopathology | TP | TP | |||
Lymph node, hilar contralateral | + | 1.4 | − | − | 0.9 | Histopathology | FP | TN | |||
6 | Primary tumor (AC) | ++ | 3.2 | ++ | 2.1 | 6.8 | Histopathology | TP | TP | Overstaged M1b | Overstaged M1b |
Lymph node, hilar ipsilateral | + | 1.7 | + | 1.3 | 1.2 | CT follow-up | TP | TP | |||
Ipsilateral lung lesion, different lobe | ++ | 3.6 | − | − | 1.9 | CT follow-up | FP | TN | |||
Bone lesion (lumbar spine) | + | 2 | + | 0.9 | 2.5 | MR imaging, spine | FP | FP | |||
7 | Primary tumor (SCC) | ++ | 5.7 | + | 1 | 4.5 | Histopathology | TP | TP | Correct | Correct |
8 | Primary tumor (SCC) | ++ | 6.5 | + | 1.3 | 5 | Histopathology | TP | TP | Correct | Correct |
Bone lesion (cervical spine) | + | 1.2 | + | 1.4 | 1.1 | MR imaging, spine | FP | FP | |||
9 | Primary tumor (AC) | + | 3 | − | − | 1.2 | Histopathology | TP | FN | Overstaged | Understaged |
Lymph node, hilar ipsilateral | ++ | 7.1 | + | 1.8 | 3.5 | Histopathology | TP | TP | |||
Lung lesion, contralateral | + | 2 | − | − | 5.3 | CT follow-up | FP | TN | |||
10 | Primary tumor (AC) | ++ | 6.2 | − | − | 3.4 | Clinical follow-up | TP | FN | Correct | Understaged |
T/BP = tumor–to–blood pool ratio; AC = adenocarcinoma; SCC = squamous cell carcinoma; TP = true positive; FN = false negative; FP = false positive; TN = true negative; ++ = markedly increased uptake; + = slightly increased uptake (more than background); − = no increased uptake.