TABLE 1

Biodistribution of ¹⁸⁸Re-Z_HER2:V2 in NMRI nu/nu Mice Bearing HER2-Expressing SKOV-3 Xenografts

	Uptake
Organ	20 min	1 h	4 h	8 h	24 h	48 h
Blood	3.0 ± 0.3	1.4 ± 0.1	0.3 ± 0.1	0.05 ± 0.02	0.02 ± 0.01	0.006 ± 0.003
Heart	1.4 ± 0.3	0.6 ± 0.1	0.11 ± 0.02	0.05 ± 0.01	0.02 ± 0.01	NM
Lung	3.4 ± 0.2	1.7 ± 0.2	0.28 ± 0.05	0.08 ± 0.03	0.03 ± 0.01	NM
Salivary gland	1.6 ± 0.5	1.1 ± 0.3	0.2 ± 0.1	0.06 ± 0.03	0.02 ± 0.01	NM
Thyroid^*	0.07 ± 0.02	0.04 ± 0.02	0.01 ± 0.001	0.01 ± 0.004	0.002 ± 0.001	NM
Liver	3.4 ± 0.3	2.2 ± 0.2	0.51 ± 0.09	0.26 ± 0.06	0.12 ± 0.03	0.06 ± 0.016
Spleen	1.5 ± 0.2	0.87 ± 0.06	0.16 ± 0.02	0.08 ± 0.01	0.03 ± 0.01	NM
Pancreas	0.8 ± 0.2	0.4 ± 0.1	0.08 ± 0.03	0.030 ± 0.003	0.01 ± 0.01	NM
Stomach	2.0 ± 0.08	1.3 ± 0.23	0.3 ± 0.1	0.08 ± 0.01	0.08 ± 0.07	NM
Small intestine	1.4 ± 0.1	0.9 ± 0.2	0.16 ± 0.08	0.08 ± 0.07	0.04 ± 0.03	NM
Large intestine	1.9 ± 0.08	1.2 ± 0.6	0.19 ± 0.05	0.3 ± 0.3	0.04 ± 0.01	0.02 ± 0.004
Kidney	47 ± 2	18 ± 3	2.1 ± 0.2	1.0 ± 0.2	0.51 ± 0.08	0.30 ± 0.12
Tumor	8.7 ± 0.9	14 ± 2	12 ± 2	8.0 ± 0.6	5 ± 2	1.8 ± 0.5
Skin	2.4 ± 0.4	1.4 ± 0.1	0.6 ± 0.5	0.10 ± 0.02	0.04 ± 0.02	0.02 ± 0.005
Muscle	0.6 ± 0.1	0.28 ± 0.03	0.06 ± 0.03	0.02 ± 0.01	0.02 ± 0.01	NM
Bone	1.0 ± 0.1	0.6 ± 0.1	0.12 ± 0.01	0.05 ± 0.02	0.04 ± 0.02	NM
Brain	0.08 ± 0.02	0.05 ± 0.01	0.020 ± 0.003	0.01 ± 0.001	0.01 ± 0.002	NM
Carcass^*	23 ± 2	14 ± 4	2 ± 1	1.1 ± 0.9	0.35 ± 0.09	0.19 ± 0.04

↵* Data for thyroid and carcass are presented as %IA per whole sample.
NM = not measurable, below detection limit.
Uptake is expressed as %IA/g and presented as average value from 4 animals ± SD. Data are corrected for decay and self-attenuation in samples.