Long-Term PRRT Toxicity in Gastroenteropancreatic NETs
| Therapy | Study | No. of patients | Follow-up (mo) | Renal toxicity | MDS (n) | Leukemia (n) |
| 90Y-octreotide | Bodei, 2003 (10) | 40 | 19 | 10% grade 1 | 0 | 0 |
| Waldherr, 2002 (9) | 39 | 6 | 3% grade 2 | 0 | 0 | |
| Valkema, 2006 (11) | 58 | 18 | 3% grade 4 | 1 | 0 | |
| Imhof, 2011 (14) | 1,109 | 23 | 9.2% grades 3/4 | 1 | 1 | |
| 177Lu-octreotate | Kwekkeboom, 2008 (4) | 504 | 19 | 0.4% grade 4 | 3 | 0 |
| Bodei, 2011 (13) | 51 | 29 | 24% grade 1 | 0 | 0 | |
| Sabet, 2013 and 2014 (5,23) | 74 | 21 | 1.3% grades 3/4 | 3 | 0 |
MDS = myelodysplastic syndrome.