TABLE 1

Pharmacokinetic Analysis in Human NSCLC–Bearing Mice

ParameterUnit188Re-BMEDA188Re-liposome
Cmax%ID/mL7.4039.72
ClmL/h1.61 ± 0.180.21 ± 0.02
AUC(0→∞)h·%ID/mL62.73 ± 7.26488.97 ± 52.83
MRT(0→∞)hours5.07 ± 3.3913.04 ± 4.32
  • Cmax = larger maximal concentration; %ID = percentage injected dose; Cl = clearance; AUC(0→∞) = area under curve; MRT(0→∞) = mean residence time.