TABLE 1

Quantitative Histologic Evaluation of A-431 Tumors During Bevacizumab Treatment

Microvascular density (vessels per 0.19 mm2)Vessel diameter (μm)Necrotic index (%)
DayControlBevacizumabControlBevacizumabControlBevacizumab
717.0 ± 4.711.5 ± 2.9*29.1 ± 4.714.5 ± 3.2**43.1 ± 25.05.1 ± 5.0**
1423.4 ± 4.99.8 ± 1.9**25.2 ± 15.015.0 ± 1.9**66.1 ± 22.245.3 ± 15.2
2112.6 ± 2.3*21.8 ± 3.972.2 ± 24.0

  • ↵* P < 0.05 for bevacizumab-treated vs. control tumors.

  • ↵** P < 0.01 for bevacizumab-treated vs. control tumors.

  • Data are mean ± SD.