TABLE 2

Whole-Lung Variables at 4 Hours of Mechanical Ventilation

	LPS−		LPS+		P
Variable	Nonlavaged lung	Lavaged lung	Nonlavaged lung	Lavaged lung	Lavage	LPS	Interaction
K_i (10⁻³/min)	1.2 ± 1.0	2.3 ± 1.7^*	4.4 ± 1.9	7.2 ± 4.3^†	<0.01	0.012	0.20
F_ei (10⁻²)	7.6 ± 2.1	12.6 ± 1.4^†^,^‡	14.7 ± 5.9	22.2 ± 8.6^§	<0.001	0.015	0.32
k₃ (10⁻²/min)	1.6 ± 1.0	1.8 ± 1.3	3.1 ± 1.6	3.6 ± 2.5	0.45	0.10	0.78
F_gas	0.73 ± 0.08	0.50 ± 0.18^§	0.59 ± 0.06	0.41 ± 0.08^§	<0.001	0.057	0.50
Perfusion fraction	0.52 ± 0.09	0.47 ± 0.09	0.56 ± 0.08	0.43 ± 0.08	0.12	0.37	0.47
Shunt	0.18 ± 0.06	0.27 ± 0.04^‡	0.33 ± 0.09	0.58 ± 0.08^†	0.013	0.023	0.20
Neutrophils/field	3.3 ± 1.9	4.9 ± 2.2^*	4.3 ± 3.3	8.7 ± 4.5^∥	<0.001	0.045	0.033

↵* P < 0.01 vs. lavaged lung of LPS+ group.
↵† P < 0.05 vs. nonlavaged lung of same group.
↵‡ P < 0.05 vs. lavaged lung of LPS+ group.
↵§ P < 0.01 vs. nonlavaged lung of same group.
↵∥ P < 0.001 vs. nonlavaged lung of same group.