TABLE 2

Biodistribution Data of ⁶⁸Ga-NOTA-MJ9 and ⁶⁸Ga-NODAGA-MJ9 in PC3 Xenografts

	⁶⁸Ga-NOTA-MJ9			⁶⁸Ga-NODAGA-MJ9
Organ	1 h	1-h blocked	2 h	1 h	1-h blocked	2 h
Blood	0.7 ± 0.1	0.3 ± 0.1	0.3 ± 0.04	0.9 ± 0.1	0.5 ± 0.3	0.3 ± 0.02
Heart	0.1 ± 0.07	0.1 ± 0.02	>0.14 ± 0.12	0.3 ± 0.1	0.2 ± 0.1	0.07 ± 0.04
Liver	0.7 ± 0.08	0.6 ± 0.2	0.5 ± 0.05	1.1 ± 0.1	0.5 ± 0.07	0.6 ± 0.1
Spleen	0.4 ± 0.04	0.2 ± 0.04	0.3 ± 0.00	1.0 ± 0.2	0.3 ± 0.03	0.5 ± 0.1
Lung	0.6 ± 0.1	0.4 ± 0.06	0.4 ± 0.02	1.0 ± 0.03	0.7 ± 0.3	0.3 ± 0.03
Kidney	3.7 ± 0.6	3.8 ± 0.7	3.2 ± 0.2	3.6 ± 0.4	3.5 ± 0.2	3.0 ± 0.3
Stomach	5.8 ± 0.4	0.2 ± 0.07	5.1 ± 0.8	5.0 ± 0.4	0.3 ± 0.2	5.2 ± 0.2
Intestine	7.6 ± 0.4	0.4 ± 0.2	6.1 ± 1.1	9.1 ± 0.3	0.4 ± 0.2	4.5 ± 0.2
Adrenal	6.5 ± 3.6	0.8 ± 0.3	6.6 ± 1.5	9.2 ± 1.7	0.3 ± 0.2	5.6 ± 0.7
Pancreas	68.6 ± 6.6	0.3 ± 0.06	41.8 ± 1.5	>64 ± 3.0	0.2 ± 0.04	41.4 ± 7.0
Muscle	0.3 ± 0.2	0.08 ± 0.06	0.3 ± 0.1	0.4 ± 0.2	0.1 ± 0.04	0.2 ± 0.03
Bone	0.6 ± 0.5	0.4 ± 0.2	1.0 ± 0.3	1.4 ± 0.5	0.2 ± 0.1	0.8 ± 0.01
PC3 tumor	23.3 ± 2.0	0.8 ± 0.2	19.6 ± 0.9	16.7 ± 2.0	0.6 ± 0.3	20.4 ± 1.2
Tumor-to-blood	35 ± 6.9		61 ± 10.8	19 ± 1.6		64 ± 10
Tumor-to-liver	32 ± 2.8		36 ± 5.0	15 ± 0.6		37 ± 4.4
Tumor-to-kidney	6.5 ± 0.8		6.3 ± 0.7	4.7 ± 0.1		6.7 ± 0.2
Tumor-to-pancreas	0.3 ± 0.01		0.5 ± 0.01	0.3 ± 0.02		0.5 ± 0.06
Tumor-to-muscle	90 ± 49		85 ± 41	46 ± 23		123 ± 22

Data are expressed in %IA/g and are presented as mean ± SD (n = 3–4).