TABLE 2

Preladenant and Tozadenant A_2A RO

		Occupancy (%) for 180 min of data			Occupancy (%) for 120 min of data
Drug	Dose (mg/kg)	LGA	SRTM	NI-LGA	LGA	SRTM	NI-LGA
Preladenant	1.0	103	100	101	102	100	101
	0.2	90	92	91	92	93	92
	0.04	69	76	73	73	78	76
	0.015	39	45	42	45	49	45
	0.015	53	56	55	52	58	56
	0.010	35	44	40	43	49	45
	0.004	32	26	27	32	27	27
	0.004	23	25	25	29	26	27
Tozadenant	10.5	95	94	94	94	94	94
	7.5	93	84	88	91	83	87
	5.0	76	68	71	76	66	69
	1.5	47	42	44	49	42	44
	1.3	43	44	46	44	43	45
	0.5	28	26	27	26	26	25