TABLE 4

BP_ND (=k₃′/k₄) of (R)-¹⁸F-Fluspidine Under Control and Blocking Conditions

	(R)-¹⁸F-fluspidine (n = 3)			(R)-¹⁸F-fluspidine + SA4503 (n = 3)
Region	k₃′ (1/min)	k₄ (1/min)	BP_ND	k₃′ (1/min)	k₄ (1/min)	BP_ND
Frontal cortex	0.068 ± 0.047	0.005 ± 0.000	14.04 ± 9.23^*	0.014 ± 0.008	0.002 ± 0.001^†	9.57 ± 5.51
Temporal cortex	0.068 ± 0.044^†	0.005 ± 0.001	15.74 ± 11.37	0.014 ± 0.006	0.003 ± 0.001^†	4.74 ± 2.28
Occipital cortex	0.069 ± 0.047	0.005 ± 0.001^*	15.21 ± 11.69^*	0.019 ± 0.015	0.003 ± 0.001^†	9.33 ± 5.29
Hippocampus	0.071 ± 0.047	0.005 ± 0.001^*	16.39 ± 12.78	0.012 ± 0.004^†	0.009 ± 0.005	1.65 ± 1.04
Striatum	0.070 ± 0.045	0.005 ± 0.001^*	14.33 ± 10.26	0.009 ± 0.04^†	0.011 ± 0.006	0.87 ± 0.30^†
Thalamus	0.076 ± 0.041	0.006 ± 0.002^‡	15.02 ± 10.26	0.007 ± 0.002^†	0.008 ± 0.003	0.89 ± 0.35^†
Colliculi	0.078 ± 0.038	0.006 ± 0.002^‡	14.78 ± 9.48^*	0.006 ± 0.001^†	0.007 ± 0.002	0.84 ± 0.42^†
Midbrain	0.080 ± 0.040	0.005 ± 0.002^‡	17.23 ± 11.95	0.011 ± 0.008^†	0.007 ± 0.001	1.76 ± 1.51^†
Pons	0.082 ± 0.048	0.004 ± 0.002^‡	26.52 ± 25.83	0.054 ± 0.059	0.009 ± 0.006	5.19 ± 2.53
Cerebellum	0.083 ± 0.050	0.006 ± 0.002^‡	17.25 ± 13.42	0.015 ± 0.008^†	0.005 ± 0.002	3.75 ± 2.62

↵* P < 0.05 vs. (S)-¹⁸F-fluspidine.
↵† P < 0.05 vs. (R)-¹⁸F-fluspidine.
↵‡ P < 0.01 vs. (S)-¹⁸F-fluspidine.