TABLE 1

Five-Point Qualitative Posttherapy Assessment Scoring System (Hopkins Criteria) for Head and Neck PET/CT

Score18F-FDG uptake patternResponse category
118F-FDG uptake at the primary site and nodes less than IJV.Complete metabolic response
2Focal 18F-FDG uptake at the primary site and nodes greater than IJV but less than liver.Likely complete metabolic response
3Diffuse 18F-FDG uptake at the primary site or nodes is greater than IJV or liver.Likely postradiation inflammation
4Focal 18F-FDG uptake at the primary site or nodes greater than liver.Likely residual tumor
5Focal and intense 18F-FDG uptake at the primary site or nodes.Residual tumor
  • Scores 1, 2, and 3, which represent complete metabolic response, likely complete metabolic response, and likely postradiation inflammation, respectively, were considered negative for tumor. Scores 4 and 5, which represent likely residual tumor and residual tumor, respectively, were considered positive for tumor. New lesion would be considered as progressive disease.