Critical Appraisal According to Research Reporting Standards for Radioembolization
| Criteria | Standard |
| Major (2 points)* | (1) Study design, (2) inclusion criteria, (3) exclusion criteria, (4) description of statistics, (5) baseline clinical evaluation, (6) baseline imaging evaluation, (7) baseline laboratory evaluation, (8) primary neoplasm, (9) performance status, (10) tumor staging, (11) distribution of tumor, (12) prior treatments, (13) concomitant therapy, (14) radioembolic microsphere used, (15) details of dosimetry, (16) imaging used for follow-up, (17) method to assess tumor response, (18) time to follow-up, (19) tumor response, (20) overall survival, (21) laboratory value changes, (22) complications, (23) description of adverse events, (24) limitations, (25) conclusions |
| Minor (1 point)* | (1) Sponsorship/funding support, (2) participating centers, (3) institutional approval, (4) HIPAA compliance, (5) method of hepatic mNET diagnosis, (6) time elapsed from diagnosis of NET to radioembolization, (7) time elapsed from diagnosis of hepatic mNET to radioembolization, (8) absorbed dose to target area, (9) absorbed dose to any tissue, (10) details of flow stasis, (11) number of treatment sessions, (12) explanation of tumor targeting, (13) imaging after preparatory angiography, (14) formula to determine lung shunt fraction, (15) posttreatment imaging, (16) technical success, (17) Kaplan–Meier overall survival curve, (18) performance status, (19) uni- or multivariate analysis, (20) severe toxicity reported separately, (21) severe toxicity reported in standardized NCI-CTCAE format, (22) details of procedures with complications, (23) description of relevant vascular anatomy and missed findings with the occurrence of radiation pneumonitis, radiation cholecystitis, or gastrointestinal ulcers, (24) cost or cost effectiveness, (25) complications reported in standardized Society of Interventional Radiology format |
↵* Total appraisal score was defined as all collected points divided by maximum points, × 100.
HIPAA = Health Insurance Portability and Accountability Act; NCI-CTCAE = National Cancer Institute Common Toxicity Criteria for Adverse Events.