Vt in Controls (n = 4), Reproducibility of Vt, and Blocking of 18F-UCB-H Binding by LEV
| Blocking of 18F-UCB-H binding by LEV at‡: | ||||||
| Brain region | Vt (mL/cm3)* | Reproducibility of Vt† | 0.1 mg/kg | 1 mg/kg | 10 mg/kg | 100 mg/kg |
| Nucleus accumbens | 10.9 ± 0.5 | 3.3 ± 15.0 | −7.3 ± 1.4 | −16.3 ± 7.1 | −35.2 ± 20.4 | −53.2 ± 9.0§ |
| Amygdala | 9.0 ± 0.3 | 3.9 ± 13.6 | −8.7 ± 5.3 | −16.0 ± 8.1 | −33.0 ± 24.4 | −49.0 ± 11.3§ |
| Cerebellum | 9.0 ± 0.2 | 2.2 ± 13.3 | −7.4 ± 3.9 | −15.6 ± 7.5 | −30.2 ± 23.7 | −43.8 ± 8.4ǁ |
| Cerebral cortex | 9.4 ± 0.4 | 3.6 ± 12.8 | −10.3 ± 6.0 | −16.3 ± 8.4 | −33.0 ± 20.5 | −48.6 ± 9.2ǁ |
| Striatum | 11.3 ± 0.5 | 3.3 ± 14.5 | −7.6 ± 4.0 | −17.1 ± 6.1 | −35.1 ± 20.2 | −53.5 ± 9.8§ |
| Hippocampus | 10.7 ± 0.5 | 3.3 ± 14.3 | −9.2 ± 5.4 | −15.7 ± 7.1 | −34.1 ± 22.2 | −52.6 ± 11.6§ |
| Hypothalamus | 9.9 ± 0.2 | 3.3 ± 13.2 | −9.9 ± 1.3 | −16.4 ± 7.7 | −36.8 ± 23.3 | −54.2 ± 9.0§ |
| Medulla | 8.5 ± 0.4 | 3.2 ± 12.1 | −8.1 ± 4.5 | −15.3 ± 7.1 | −28.3 ± 17.5 | −34.4 ± 9.2ǁ |
| Olfactory bulbs | 9.0 ± 0.2 | 4.4 ± 12.0 | −6.8 ± 2.5 | −15.0 ± 7.1 | −27.4 ± 22.3 | −41.9 ± 9.2ǁ |
| Pons | 8.2 ± 0.3 | 5.2 ± 12.4 | −14.1 ± 0.2 | −15.9 ± 5.4 | −29.3 ± 8.7ǁ | −35.2 ± 11.7§ |
| Septum | 10.5 ± 0.4 | 4.6 ± 18.4 | −6.9 ± 6.6 | −16.9 ± 7.0 | −33.4 ± 21.7 | −50.8 ± 10.0ǁ |
| Thalamus | 12.1 ± 0.6 | 2.5 ± 14.0 | −10.8 ± 4.3 | −16.1 ± 5.7 | −36.2 ± 21.5 | −55.8 ± 10.3§ |
| Whole-brain average | 9.8 ± 0.5 | 3.6 ± 13.1 | −9.0 ± 4.6 | −13.3 ± 3.3 | −25.7 ± 28.0 | −43.8 ± 4.7ǁ |
↵* Determined by Logan graphic analysis and reported as mean ± SD.
↵† Determined as percentage difference in test–retest study and reported as mean ± SD.
↵‡ Determined by Logan graphic analysis as percentage change in Vt in test–retest study and reported as mean ± SD.
↵§ P value, determined by 1-way ANOVA and Tukey post hoc test, was less than 0.01.
↵ǁ P value, determined by 1-way ANOVA and Tukey post hoc test, was less than 0.05.