Comparisons Between Experimental Data and Compartmental Model Predictions
| Nadir | Rebound | ||||||||||
| Time (days after injection) | Depletion (%) | Time (days after injection) | Maximum fold increase | Return to baseline (days after injection) | |||||||
| Cell name | Dose (Gy) | Experimentations | Model simulation | Experimentations | Model simulation | Experimentations | Model simulation | Experimentations | Model simulation | Experimentations | Model simulation |
| GEMM | 2.9 | 0–14 | 4 | 88.1 | 85.5 | — | — | — | — | 14–21 | 18 |
| 4.7 | 0–14 | 4.8 | 96.8 | 96.9 | — | — | — | — | 14–21 | 23.6 | |
| Megakaryocytes | 2.9 | 0–14 | 7 | 40.2 | 39.0 | — | — | — | — | 14–21 | 16.2 |
| 4.7 | 3–14 | 7 | 55.5 | 56.2 | — | — | — | — | 14–21 | 16.8 | |
| Platelets | 2.1 | 3–14 | 9.2 | 41.6 | 44.5 | — | — | — | — | 17–21 | 22 |
| 3.4 | 3–14 | 9.8 | 64.4 | 67.4 | — | — | — | — | 21–24 | 27 | |
| Reticulocytes | 2.1 | 0–10 | 2.4 | 70.7 | 68.4 | 10–17 | 6.4–15 | 1.4 | 1.5 | 10–17 | 15 |
| 3.4 | 0–7 | 3 | 89.0 | 87.5 | 7–21 | 7.6–16.6 | 1.9 | 1.8 | 10–21 | 16.6 | |
| RBCs | 2.1 | 0–7 | 5.9 | 12.8 | 10.0 | — | — | — | — | 7–10 | 12 |
| 3.4 | 0–10 | 7.1 | 14.7 | 16.3 | — | — | — | — | 10–14 | 13.8 | |
Data from experimentations were compared with model simulations for cellular events for 2 BM absorbed doses. For experimental data, event time values are presented as time intervals defined by experimentation sampling, and depletion percentages are given as means of irradiated mice normalized to controls.