TABLE 3

Vd of ¹²⁵I-IL-13PE After Bolus Injection or CED into Mouse Brain

		Injection parameter			SPECT		Autoradiography
Group	Day	Time	Volume of injection (μL)^*	ID (kBq)	Vd (mm³)	No. of mice	Vd (mm³)	No. of mice
Bolus injection in tumor	1	10 min	5	925	3.11 ± 0.70^*	4	9.78	1
	7	10 min	5	925	Not available	6	1.09 ± 0.40^†	3
CED in tumor	1	3 d	100	3,700	18.3 ± 1.37^*	4	36.6	1
	7	3 d	100	3,700	12.0 ± 3.43	6	18.4 ± 2.41^†	3
CED in normal brain	1	3 d	100	3,700	11.7	1	Not available	0
	7	3 d	100	3,700	10.9 ± 4.97	4	14.3 ± 5.42^†	2

*,^†Significant difference between groups (P < 0.001).
↵* Normalized Vd of CED is 4.58 ± 0.34 in tumor on day 1 (P < 0.05).
↵† Normalized Vds of CED are 4.60 ± 0.60 in tumor and 3.56 ± 1.36 in normal brain on day 7 (P < 0.01).