Kinetic Rate Constants and VTs of 18F-MCL-524
| 1TCM | 2TCM | GA | ||||||||
| Region | Subject | K1 (mL·cm−3·min−1) | k2 (min−1) | SSR | AIC | VT (mL·cm−3) | SSR | AIC | VT (mL·cm−3) | VT (mL·cm−3) |
| Striatum | M1 | 0.26 (0.9) | 0.015 (2.0) | 791 | −14 | 17.1 (1.6) | 793 | −9 | 17.2 (2.4) | 15.8 (0.23) |
| M2 | 0.30 (1.7) | 0.020 (3.2) | 1,388 | 24 | 14.9 (2.3) | 1,369 | 29 | 14.9 (3.1) | 14.7 (0.29) | |
| M3 | 0.22 (1.4) | 0.012 (3.1) | 460 | 8 | 17.4 (2.3) | 474 | 14 | 17.4 (2.5) | 15.6 (0.38) | |
| Mean | 0.26 (1.3) | 0.016 (2.7) | 880 | 6 | 16.5 (2.0) | 879 | 11 | 16.5 (2.7) | 15.4 (0.30) | |
| Cerebellum | M1 | 0.21 (0.9) | 0.044 (1.8) | 247 | −11 | 4.8 (1.3) | 239 | −7 | NA | 4.8 (0.40) |
| M2 | 0.29 (1.9) | 0.067 (4.6) | 1,490 | 63 | 4.4 (4.4) | 1,501 | 68 | 4.3 (4.4) | 4.7 (0.70) | |
| M3 | 0.23 (0.7) | 0.039 (1.4) | 89 | −18 | 5.8 (1.2) | 89 | −13 | 5.8 (2.2) | 5.6 (0.29) | |
| Mean | 0.24 (1.2) | 0.050 (2.6) | 609 | 11 | 5.0 (2.3) | 610 | 16 | 5.0 (3.3) | 5.0 (0.46) | |
SSR = sum of squared residuals; AIC = Akaike information criterion; NA = not available (2TCM could not calculate reasonable VT).
SE coefficients of variation are presented between parentheses.