TABLE 1

Kinetic Parameters of 18F− Uptake in Mice Bearing MDA-MB-231 Tumors (Tumors Contain Hydroxyapatite Similar to What Is Found in Normal Bone)

RegionK1 (mL/g/min)k2 (1/min)k3 (1/min)k4 (1/min)K18F (mL/g/min)
Tumor0.42 ± 0.191.27 ± 0.920.07 ± 0.060.03 ± 0.020.03 ± 0.01
Bone0.25 ± 0.110.44 ± 0.120.60 ± 0.420.002 ± 0.0020.14 ± 0.08

  • Data are mean ± SD. K18F is 18F− uptake constant described as K1k2/(k2 + k3).