Comparison of 18F-EF5 Uptake with EF5 Binding and Hypoxia in 3 Tumor Models
| Spatial correlation | ||||||
| 18F-EF5 vs. EF5 | 18F-EF5 vs. Hoechst | |||||
| Tumor type | 18F-EF5 uptake area fraction (DAR) | EF5 staining area fraction (immunohistochemistry) | r | Slope | r | Slope |
| PC3 (n = 3) | 0.36 ± 0.10 | 0.32 ± 0.06 | 0.73 ± 0.02 | 0.99 ± 0.13 | −0.12 ± 0.21 | −0.10 ± 0.13 |
| HCT116 (n = 3) | 0.41 ± 0.03 | 0.24 ± 0.04 | 0.60 ± 0.06 | 0.66 ± 0.12 | −0.09 ± 0.11 | −0.04 ± 0.02 |
| H460 (n = 4) | 0.47 ± 0.05 | 0.32 ± 0.05 | 0.53 ± 0.10 | 0.56 ± 0.13 | −0.06 ± 0.07 | −0.02 ± 0.04 |