BPND | |||||||||
Condition | Blocking drug dose (mg/kg) | Globus pallidus | Caudate | Putamen | Cingulate cortex | Insula | Frontal cortex | Temporal cortex | Thalamus |
Baseline (n = 6) | — | 2.18 ± 0.23 | 1.04 ± 0.13 | 1.03 ± 0.15 | 1.39 ± 0.25 | 1.08 ± 0.09 | 0.59 ± 0.09 | 0.51 ± 0.08 | 0.50 ± 0.11 |
Naloxone (n = 2) | 1.0 | 0.20 ± 0.04 | 0.13 ± 0.02 | 0.23 ± 0.00 | 0.14 ± 0.07 | 0.07 ± 0.01 | 0.02 ± 0.03 | −0.03 ± 0.02 | 0.10 ± 0.03 |
LY2456302 (n = 1) | 0.03 | 0.64 | 0.37 | 0.32 | 0.53 | 0.31 | 0.15 | 0.09 | 0.34 |
LY2456302 (n = 1) | 0.3 | 0.09 | 0.10 | 0.16 | 0.11 | 0.01 | −0.02 | −0.04 | 0.12 |
LY2459989 (n = 2) | 0.036 | 0.67 ± 0.22 | 0.36 ± 0.25 | 0.30 ± 0.19 | 0.44 ± 0.30 | 0.31 ± 0.23 | 0.16 ± 0.17 | 0.10 ± 0.11 | 0.25 ± 0.20 |
11C-LY2795050 baseline (n = 4)* | 0.97 ± 0.10 | 0.32 ± 0.26 | 0.66 ± 0.25 | 0.63 ± 0.21 | 0.39 ± 0.17 | 0.30 ± 0.16 | 0.15 ± 0.12 | — |
↵* Taken from Zheng et al. (29).
Data are mean ± SD, where applicable.