Organ | 1 h | 1 h blocked | 1 h/Gelofusine | 1 h/vildagliptin | 2 h |
Blood | 0.6 ± 0.1 | 0.6 ± 0.2 | 1.4 ± 0.4 | 0.4 ± 0.2 | 0.03 ± 0.02 |
Heart | 0.1 ± 0.03 | 0.05 ± 0.3 | 0.6 ± 0.01 | 0.2 ± 0.1 | 0.03 ± 0.02 |
Liver | 3.3 ± 0.6 | 2.0 ± 0.5 | 4.6 ± 2.8 | 2.8 ± 0.6 | 3.1 ± 1.3 |
Spleen | 5.2 ± 2.3 | 2.9 ± 0.2 | 4.6 ± 1.5 | 5.4 ± 1.1 | 5.9 ± 3.9 |
Lung | 5.5 ± 2.3 | 2.9 ± 0.3 | 5.0 ± 0.3 | 6.9 ± 3.8 | 6.6 ± 3.9 |
Kidney | 283 ± 25 | 281 ± 48 | 191 ± 32 | 152 ± 24 | 295 ± 33 |
Stomach | 1.3 ± 0.8 | 0.6 ± 0.16 | 1.2 ± 0.8 | 0.7 ± 0.6 | 0.05 ± 0.02 |
Intestine | 1.1 ± 0.6 | 1.1 ± 0.1 | 0.8 ± 0.5 | 0.7 ± 0.3 | 0.4 ± 0.04 |
Adrenal glands | 0.01 ± 0.00 | 1.4 ± 0.7 | 0.00 ± 0.00 | 1.2 ± 0.8 | 0.01 ± 0.00 |
Pancreas | 0.7 ± 0.5 | 0.2 ± 0.06 | 0.08 ± 0.01 | 0.4 ± 0.3 | 0.04 ± 0.01 |
Muscle | 0.07 ± 0.03 | 0.05 ± 0.01 | 0.05 ± 0.01 | 0.07 ± 0.02 | 0.01 ± 0.00 |
Bone | 0.3 ± 0.5 | 1.5 ± 0.6 | 0.01 ± 0.00 | 1.0 ± 0.5 | 0.07 ± 0.02 |
INR1G9 tumor | 17.0 ± 4.4 | 1.3 ± 0.3 | 15.8 ± 5.4 | 13.4 ± 3.8 | 6.8 ± 1.1 |
Tumor/blood | 35 ± 4 | 12 ± 8 | 23 ± 2 | 233 ± 77 | |
Tumor/lung | 4 ± 1.5 | 2.4 ± 1 | 2.3 ± 1.9 | 1.1 ± 0.6 | |
Tumor/kidney | 0.05 ± 0.01 | 0.07 ± 0.06 | 0.09 ± 0.04 | 0.02 ± 0.01 | |
Tumor/muscle | 291 ± 68 | 276 ± 37 | 219 ± 47 | 677 ± 106 |
Data are presented as mean ± SD (n = 4) %IA/g of tissue; blocking studies were performed in presence of 20 nmol of GIP(1–30).