TABLE 3.
Biodistribution of 99mTc-EGFR-PNA in MDA-MB-435S Xenografts
| Organ | 1 h | 2 h | 4 h | 6 h |
| Heart | 0.99 ± 0.15 | 0.50 ± 0.08 | 0.39 ± 0.06 | 0.34 ± 0.08 |
| Blood | 1.12 ± 0.16 | 0.72 ± 0.10 | 0.59 ± 0.09 | 0.43 ± 0.08 |
| Liver | 10.45 ± 1.24 | 7.76 ± 0.79 | 6.80 ± 0.37 | 3.82 ± 0.42 |
| Spleen | 3.39 ± 0.39 | 2.44 ± 0.39 | 1.60 ± 0.10 | 1.23 ± 0.13 |
| Kidney | 8.59 ± 0.64 | 7.88 ± 0.54 | 6.46 ± 0.44 | 3.11 ± 0.49 |
| Lung | 0.82 ± 0.14 | 0.72 ± 0.08 | 0.57 ± 0.08 | 0.29 ± 0.07 |
| Stomach | 1.86 ± 0.13 | 1.12 ± 0.19 | 0.81 ± 0.16 | 0.32 ± 0.08 |
| Intestine | 2.11 ± 0.13 | 1.19 ± 0.28 | 0.64 ± 0.11 | 0.55 ± 0.06 |
| Brain | 0.15 ± 0.05 | 0.11 ± 0.05 | 0.08 ± 0.02 | 0.07 ± 0.04 |
| Bone | 1.14 ± 0.12 | 0.87 ± 0.14 | 0.57 ± 0.07 | 0.30 ± 0.08 |
| Muscle | 0.80 ± 0.12 | 0.41 ± 0.07 | 0.37 ± 0.05 | 0.14 ± 0.03 |
| Tumor | 0.98 ± 0.10 | 0.95 ± 0.13 | 0.94 ± 0.99 | 0.52 ± 0.09 |
Values are mean ± SD (
± SD) and expressed as %ID/g (n = 6).
