TABLE 4

SUVRs of 11C-AZD2184 in Control Subjects and AD Patients

ControlAD
SUVRSUVR
Brain region20–40 min*40–60 min*60–90 min*DVR20–40 min*40–60 min*60–90 min*DVR
Frontal cortex1.04 ± 0.041.07 ± 0.090.99 ± 0.100.99 ± 0.072.16 ± 0.28†2.17 ± 0.27†2.13 ± 0.28†1.96 ± 0.25†
Temporal cortex1.10 ± 0.041.14 ± 0.041.08 ± 0.071.07 ± 0.062.09 ± 0.23†2.14 ± 0.25†2.15 ± 0.30†1.97 ± 0.26†
Parietal cortex1.06 ± 0.071.08 ± 0.101.03 ± 0.091.03 ± 0.091.93 ± 0.30†1.98 ± 0.38†2.01 ± 0.44†1.84 ± 0.37†
Occipital cortex1.13 ± 0.061.21 ± 0.081.11 ± 0.101.12 ± 0.091.87 ± 0.38†1.97 ± 0.33†2.01 ± 0.38†1.86 ± 0.33†
Hippocampus1.15 ± 0.071.18 ± 0.051.15 ± 0.071.11 ± 0.071.52 ± 0.11†1.52 ± 0.15†1.58 ± 0.16†1.43 ± 0.15†
Posterior cingulate1.19 ± 0.081.24 ± 0.131.17 ± 0.121.16 ± 0.112.46 ± 0.44†2.54 ± 0.43†2.56 ± 0.42†2.39 ± 0.42†
Centrum semiovale1.41 ± 0.081.49 ± 0.141.36 ± 0.171.30 ± 0.121.68 ± 0.191.72 ± 0.211.64 ± 0.221.51 ± 0.22

  • ↵* Integration interval.

  • ↵† Significant differences from normal control subjects (unpaired t test, P < 0.01).

  • Values are mean ± SD.