Calculated Fraction of I2BS Occupied by BU224 Using 11C-BU99008
| Percentage occupancy | ||||||||
| BU224 dose (mg/kg) | Whole brain | Globus pallidus | Frontal cortex | Cerebellum | ||||
| 0.01 | 35 (1) | 25 (2) | 38 (1) | 32 (2) | 32 (1) | 24 (2) | 30 (1) | 27 (2) |
| 0.03 | 54 (1)* | 66 (2) | 50 (1)* | 61 (2) | 48 (1)* | 65 (2) | 47 (1)* | 54 (2) |
| 0.1 | 81 (2) | 74 (2) | 73 (2) | 64 (2) | ||||
| 0.3 | 93 (1) | 85 (1) | 75 (1) | 72 (1) | ||||
| ED50 | 0.022 | 0.017 | 0.017 | 0.016 | ||||
↵* Percentage occupancies generated from averaged composite of baseline scans for monkey 1 due to failure to obtain baseline scan on this study day.
Number in parentheses indicates animal used to derive value: monkey 1 (1) and monkey 2 (2). Whole-brain occupancy was calculated using occupancy plot (17) and is derived from slope for all reported brain regions. Values calculated from VT determined using MA1 model.