TABLE 2

Association of Type 2 Diabetes with Abnormal ¹⁸F-FDG PET Ratio^* in AD Signature Meta-ROI

	Covariates included in each model
Group	Age and sex	Education	APOE ε4	Glucose	Cognition	Full model 1^†	Full model 2^†
Total sample
OR	2.24	2.28	2.26	1.73	2.17	1.78	1.69
95% CI	1.54–3.27	1.56–3.33	1.55–3.30	1.13–2.63	1.48–3.18	1.17–2.72	1.10–2.60
P	<0.001	<0.001	<0.001	0.01	<0.001	0.008	0.02
CN
OR	2.21	2.22	2.20	1.50	NA	1.50	NA
95% CI	1.42–3.43	1.43–3.45	1.42–3.41	0.91–2.49		0.91–2.49
P	0.0004	0.0004	0.0005	0.12		0.12
MCI
OR	2.02	2.22	2.31	1.96	NA	2.62	NA
95% CI	0.93–4.41	1.00–4.92	1.03–5.18	0.85–4.51		1.08–6.38
P	0.08	0.05	0.04	0.11		0.03

↵* AD signature meta-ROI ¹⁸F-FDG ratio < 1.31.
↵† All models include adjustment for age and sex; columns 3–6 show variables added separately to model with age and sex. Full model 1 is adjusted for age, sex, education, APOE ε4 allele, and glucose level. Full model 2 includes variables in full model 1 and cognition (MCI or normal cognition).