In Vitro I2BS Binding Affinities of Blocking Drugs in Rat and Nonhuman Primate Brain Using 3H-BU99008
| IC50 ± SD (nM) | |||
| Protein target | Blocking drug | Rat | Cynomolgus |
| I2BS | BU224 | 50.5 ± 12.9 (high) | 130.2 ± 33.9 |
| 9,596 ± 2,494 (low) | |||
| MAOA | Moclobemide | >100,000 | >100,000 |
| MAOB | Lazabemide | 6,445 ± 1,733 | 17,370 ± 2,068 |
Displacement of 3H-BU99008 by BU224 was best fit to 2-site model in rat only; for all other instances data were best fit to 1-site model (n = 4).
IC50 = half maximal inhibitory concentration.