HSA 123I-Iobenguane Pharmacokinetic Parameters in Healthy Adult Humans
| Parameter | Women (n = 6) | Men (n = 6) | All subjects |
| Tmax (h) | 0.20 ± 0.11 | 0.25 ± 0.12 | 0.22 ± 0.12 |
| Peak plasma concentration (Bq/mL) | 3,034 ± 1,554 | 2,553 ± 1,628 | 2,886 ± 1,665 |
| Area under curve, 0–∞ (h × MBq/mL) | 0.15 ± 0.04 | 0.08 ± 0.04 | 0.11 ± 0.06 |
| Clearance (mL/h/kg) | 30.3 ± 7.16 | 82.8 ± 58.4 | 58.1 ± 50.2 |
| Steady-state volume of distribution (mL/kg) | 3,993 ± 923.6 | 5,550 ± 810.2 | 4,853 ± 1,180 |
| t½ (h) | 93.9 ± 15.8 | 61.4 ± 25.5 | 78.4 ± 27.5 |
| Mean residence time, 0–∞ (h) | 133.4 ± 22.52 | 85.94 ± 36.31 | 110.7 ± 39.7 |
| t½ α (h) | 0.21 ± 0.09* | 0.24 ± 0.10 | 0.22 ± 0.09 |
| t½ β (h) | 101.7 ± 32.1* | 59.6 ± 20.6 | 78.7 ± 33.3 |
| Urine (% injected dose at 24 h) | 51.8 ± 8.79 | 55.7 ± 10.5 | 53.7 ± 9.46 |
| Urine (% injected dose at 48 h) | 65.5 ± 12.3 | 69.1 ± 11.8 | 67.3 ± 11.6 |
↵* n = 5 for this value because data were not calculated for first female subject.