TABLE 3

Associations of Type 2 Diabetes with Abnormal ¹¹C-PiB PET Retention Ratio^* in AD Signature Meta-ROI

	Covariates included in each model^†
Group	Age and sex	Education	APOE ε4	Full model
Total sample
OR	1.02	1.03	1.05	1.06
95% CI	0.70–1.49	0.71–1.51	0.70–1.57	0.71–1.59
P	0.91	0.87	0.82	0.78
CN
OR	1.26	1.28	1.26	1.28
95% CI	0.82–1.95	0.83–1.97	0.80–1.99	0.81–2.02
P	0.30	0.27	0.32	0.29
MCI
OR	0.39	0.39	0.46	0.46
95% CI	0.17–0.88	0.17–0.90	0.18–1.16	0.18–1.16
P	0.02	0.03	0.10	0.10

↵* AD signature ¹¹C-PiB ratio > 1.50.
↵† All models include adjustment for age and sex; columns 3 and 4 show variables added separately to model with age and sex. Full model is adjusted for age, sex, education, and APOE ε4 allele.