TABLE 3

Univariate Cox Regression Analysis for Clinicopathologic Risk Factors Associated with Survival

		RFS			OS
Variable	n	Hazard ratio	95% CI	P	Hazard ratio	95% CI	P
Age (y)	120	1.009	0.987−1.032	0.428	1.034	1.000−1.069	0.052
Sex
Female	38	—	—	—	—	—	—
Male	82	1.462	0.885−2.414	0.138	1.308	0.639−2.677	0.462
Size of primary tumor (cm)	120	1.034	0.908−1.176	0.617	0.982	0.826−1.168	0.838
Size of hepatic metastasis (cm)	120	1.088	0.998−1.187	0.055	1.131	1.016−1.259	0.025
Preoperative serum carcinoembryonic antigen (ng/mL)	120	1.001	0.999−1.003	0.298	1.002	0.999−1.004	0.179
T stage
T2, T3	108	—	—	—	—	—	—
T4	12	1.194	0.595−2.396	0.617	1.019	0.361−2.876	0.972
N stage
N0	29	—	—	0.822	—	—	0.776
N1	47	0.881	0.494−1.571	0.667	1.281	0.557−2.947	0.560
N2	44	1.031	0.578−1.839	0.919	1.035	0.434−2.471	0.937
Positive hepatic resection margin
No	107	—	—	—	—	—	—
Yes	13	1.315	0.656−2.639	0.440	1.518	0.637−3.620	0.346
No. of hepatic metastasis	120	1.200	1.009−1.427	0.039	1.058	0.858−1.304	0.596
Bilobar hepatic metastasis
No	99	—	—	—	—	—	—
Yes	21	0.886	0.488−1.609	0.691	0.735	0.288−1.880	0.521
Differentiation grade
Well or moderately differentiated	114	—	—	—	—	—	—
Poorly differentiated	6	1.934	0.703−5.324	0.202	5.234	1.803−15.196	0.002
Location of primary tumor
Colon	74	—	—	—	—	—	—
Rectum	46	1.265	0.803−1.992	0.310	0.986	0.524−1.857	0.966
Adjuvant chemotherapy
No	4	—	—	—	—	—	—
Yes	116	0.585	0.214−1.605	0.298	0.414	0.099−1.738	0.228
Fong’s clinical risk score	120	1.225	0.891−1.683	0.214	1.310	0.850−2.021	0.224