TABLE 1

Patient Characteristics and Hepatic Removal Kinetics of Galactose and LC for ¹⁸F-FDGal in Patients with Liver Disease

Patient no.	Sex	Age (y)	Body weight (kg)	Etiology	V_max (mmol/min)	K_m (mmol/L of blood)	V_max/K_m (L of blood/min)	LC
1	Male	61	70	Alcohol	1.52 ± 0.40	0.81 ± 0.40	1.88 ± 0.33	0.18 ± 0.05
2	Male	66	86	Alcohol	1.56 ± 0.17	0.93 ± 0.19	1.68 ± 0.14	0.23 ± 0.03
3	Female	60	82	Cryptogenic	1.01 ± 0.10	1.00 ± 0.22	1.00 ± 0.13	0.23 ± 0.04
4	Male	57	79	Alcohol + HCV	1.48 ± 0.52	1.41 ± 0.77	1.05 ± 0.25	0.27 ± 0.08
5	Female	71	83	Cryptogenic	2.16 ± 0.27	1.96 ± 0.43	1.10 ± 0.12	0.29 ± 0.05
6	Male	51	93	Alcohol	1.17 ± 0.22	0.48 ± 0.20	2.42 ± 0.39	0.18 ± 0.04
7	Male	62	90	Alcohol	1.19 ± 0.18	0.82 ± 0.26	1.45 ± 0.24	0.22 ± 0.08
8	Male	65	62	Alcohol	0.95 ± 0.11	1.19 ± 0.22	0.79 ± 0.08	0.28 ± 0.03
9	Male	43	70	Alcohol	1.75 ± 0.35	0.80 ± 0.23	2.17 ± 0.16	ND
Mean ± SE					1.18 ± 0.06^†	0.91 ± 0.08	1.18 ± 0.05^‡	0.24 ± 0.02^§
Healthy subjects
Mean					2.66	0.95	2.74	0.13
Range					1.81–5.34	0.59–2.17	2.16–3.13	0.10–0.17

↵† P < 0.01 when compared with healthy subjects.
↵‡ P < 0.001 when compared with healthy subjects.
↵§ P < 0.0001 when compared with healthy subjects.
HCV = hepatitis C virus; ND = intrinsic clearance of ¹⁸F-FDGal could not be determined (7); mean ± SE = weighted mean ± SE of weighted mean.
V_max and K_m were calculated according to Equation 2; LC was calculated according to Equation 1. Individual data are given as mean ± SE of estimate. Data from healthy subjects are from Sørensen et al. (3).