TABLE 1

Effect of 10 mg of Trastuzumab on Radioiodinated Nanobody Uptake in BT474M1 Xenografts and Normal Tissues

	Experiment 1				Experiment 2
	¹²⁵I-Nanobody (185 kBq, 0.6 μg)		¹³¹I-SGMIB-Nanobody (185 kBq, 1.0 μg)		¹²⁵I-SGMIB-Nanobody (93 kBq, 1.6 μg)		¹³¹I-IB-Mal-d-GEEK-Nanobody (150 kBq, 0.7 μg)
Tissue	Not blocked	Blocked	Not blocked	Blocked	Not blocked	Blocked	Not blocked	Blocked
Liver	7.76 ± 1.56	6.28 ± 0.72	2.65 ± 0.65	2.45 ± 0.34	1.95 ± 0.42	1.72 ± 0.11	13.32 ± 1.75	12.71 ± 0.76
Spleen	3.90 ± 1.77	3.32 ± 0.49	1.13 ± 0.47	1.03 ± 0.37	1.09 ± 0.29	0.92 ± 0.14	2.68 ± 0.38	2.99 ± 0.86
Kidneys	26.05 ± 5.86	21.54 ± 1.09	44.0 ± 12.0	42.30 ± 4.66	34.98 ± 5.57	36.89 ± 5.48	174.8 ± 28.2	197.2 ± 22.4
Blood	10.08 ± 1.47	6.56 ± 0.65^*	1.15 ± 0.25	1.04 ± 0.16	0.70 ± 0.10	0.69 ± 0.09	0.69 ± 0.09	0.70 ± 0.09
Tumor	6.39 ± 1.97	2.27 ± 0.22^*	24.50 ± 9.89	2.14 ± 0.21^*	12.57 ± 2.77	1.26 ± 0.13^*	6.23 ± 1.32	0.68 ± 0.06^*

↵* Significant blocking effect (P < 0.05).
Data are %ID/g (mean ± SD; n = 5).