VAChT Binding Estimates
BPND (from k3/k4) | DVR (from VT/Vref) (∼1 + BPND) | ||||||
Subject | Striatum | Thalamus | Motor cortex | Cerebellar gray matter | Striatum | Thalamus | Motor cortex |
1 | 25.9 | 3.84 | 1.69 | 0.98 | 13.6 | 2.45 | 1.36 |
2 | 33.0 | 3.10 | 1.26 | 0.87 | 18.2 | 2.19 | 1.21 |
3 | 15.2 | 2.81 | 2.12 | 0.76 | 9.2 | 2.16 | 1.77 |
4 | 32.5 | 5.72 | 1.98 | 1.01 | 16.7 | 3.34 | 1.48 |
5 | 27.5 | 3.71 | 1.64 | 0.67 | 17.1 | 2.82 | 1.59 |
6 | 29.2 | 5.03 | 2.23 | 1.17 | 13.9 | 2.78 | 1.49 |
7 | 13.5 | 2.30 | 0.74 | 0.42 | 10.2 | 2.32 | 1.23 |
Mean | 25.3 | 3.79 | 1.67 | 0.84 | 14.1 | 2.58 | 1.45 |
SD | 7.87 | 1.22 | 0.52 | 0.25 | 3.45 | 0.43 | 0.20 |
Coefficient of variation | 31.2% | 32.2% | 31.3% | 29.4% | 24.5% | 16.5% | 13.8% |
Values are derived from kinetic parameter values of Table 1. BPND values in left side of table are calculated directly from ratio k3/k4. On right side of table, DVR (1 + BPND) values are calculated from ratio of total volume of distribution estimates for target and reference tissues (VT/Vref).