TABLE 3

VAChT Binding Estimates

BPND (from k3/k4)DVR (from VT/Vref) (∼1 + BPND)
SubjectStriatumThalamusMotor cortexCerebellar gray matterStriatumThalamusMotor cortex
125.93.841.690.9813.62.451.36
233.03.101.260.8718.22.191.21
315.22.812.120.769.22.161.77
432.55.721.981.0116.73.341.48
527.53.711.640.6717.12.821.59
629.25.032.231.1713.92.781.49
713.52.300.740.4210.22.321.23
Mean25.33.791.670.8414.12.581.45
SD7.871.220.520.253.450.430.20
Coefficient of variation31.2%32.2%31.3%29.4%24.5%16.5%13.8%
  • Values are derived from kinetic parameter values of Table 1. BPND values in left side of table are calculated directly from ratio k3/k4. On right side of table, DVR (1 + BPND) values are calculated from ratio of total volume of distribution estimates for target and reference tissues (VT/Vref).