Frequency of Adverse Events
| Grade | ||||
| Parameter | Cycle | I | II | III |
| No. of CTCAEs | ||||
| HCC (n = 8) | 1 | 16 | 5 | 1 |
| 2 | 25 | 2 | 0 | |
| Metastases/cholangiocellular carcinoma (n = 13) | 1 | 28 | 6 | 1 |
| 2 | 31 | 12 | 1 | |
| Percentage of patients (%) | ||||
| HCC (n = 8) | 1 | 75 | 50 | 13 |
| 2 | 100 | 25 | — | |
| Metastases/cholangiocellular carcinoma (n = 13) | 1 | 92 | 38 | 8 |
| 2 | 92 | 54 | 8 | |