TABLE 1

Binding Parameters of antiTEM1 IgG1 MORAb-004 mAb to Live MS1 Cells Expressing hTEM1*

mAbSpecific activity (MBq/mg)Kd (nM)Bmax (× 105 mAb/cell)Immunoreactivity†
125I-MORAb-004 (n = 5)150–2253.41 ± 1.206.28 ± 2.1490.1% ± 4.8%
124I-MORAb-004 (n = 3)1920–22203.41 ± 0.937.52 ± 1.9290.1% ± 1.5%

  • ↵* MS1 cells used as binding control; results expressed as mean ± SD.

  • ↵† Immunoreactivity = Kd 125/124I-MORAb-004/Ki unlabeled MORAb-004.