44-Hour Biodistribution of Male Nude Mice Bearing 22Rv1 (Negative) and 22Rv1×PSCA (Positive) Xenografts
| 124I-A11 | 89Zr-A11 | ||||
| Organ | n | %ID/g ± SD | n | %ID/g ± SD | P |
| 22Rv1×PSCA | 11 | 3.62 ± 1.18 | 4 | 7.87 ± 0.52 | <0.0001 |
| 22Rv1 | 8 | 0.34 ± 0.26 | 4 | 1.63 ± 0.18 | <0.0001 |
| Blood | 13 | 0.41 ± 0.11 | 4 | 0.26 ± 0.05 | 0.03 |
| Liver | 13 | 0.12 ± 0.02 | 4 | 9.19 ± 0.74 | <0.0001 |
| Kidney | 13 | 0.21 ± 0.08 | 4 | 23.39 ± 2.82 | <0.0001 |
| Spleen | 10 | 0.14 ± 0.04 | 4 | 4.22 ± 1.50 | <0.0001 |
| Heart | 13 | 0.12 ± 0.04 | 4 | 2.54 ± 0.33 | <0.0001 |
| Lung | 11 | 0.37 ± 0.12 | 4 | 1.64 ± 0.24 | <0.0001 |
| Stomach | 10 | 0.19 ± 0.07 | 4 | 0.99 ± 0.17 | <0.0001 |
| Bladder | 8 | 0.17 ± 0.09 | 4 | 2.11 ± 0.55 | <0.0001 |
| Prostate | 8 | 0.11 ± 0.03 | 4 | 1.17 ± 0.14 | <0.0001 |
| Testicles | 5 | 0.11 ± 0.03 | 4 | 3.98 ± 1.57 | 0.001 |
| Small intestine | 5 | 0.07 ± 0.02 | 4 | 1.20 ± 0.13 | <0.0001 |
| Large intestine | 5 | 0.07 ± 0.03 | 4 | 1.64 ± 0.70 | 0.001 |
| Bone | 5 | 0.02 ± 0.01 | 4 | 2.54 ± 0.28 | <0.0001 |
| Muscle | 12 | 0.03 ± 0.01 | 4 | 0.50 ± 0.08 | <0.0001 |
| Carcass | 13 | 0.10 ± 0.03 | 4 | 1.39 ± 0.11 | <0.0001 |
| Ratio (unitless) | |||||
| Positive-to-negative tumor | 5 | 13.31 ± 5.59 | 4 | 4.87 ± 0.52 | 0.02 |
| Tumor to blood | 11 | 8.65 ± 2.62 | 4 | 30.36 ± 5.05 | <0.0001 |
| Tumor to muscle | 10 | 133.33 ± 51.9 | 4 | 15.86 ± 2.10 | 0.0008 |