Uptake Ratios of Brain to Blood, Brain to Plasma, Heart to Blood, and Heart to Plasma of 18F-BCPP-EF, 18F-BCPP-BF, and 18F-BMS in Rat
| Probe | 1 min | 5 min | 10 min | 30 min | 60 min |
| 18F-BCPP-EF | |||||
| Brain to blood | 7.643 ± 0.495 | 15.058 ± 1.358 | 15.525 ± 2.178 | 7.866 ± 0.453 | 4.411 ± 0.435 |
| Brain to plasma | 5.280 ± 0.217 | 11.703 ± 1.361 | 11.879 ± 1.559 | 5.941 ± 0.502 | 3.328 ± 0.642 |
| Heart to blood | 26.785 ± 1.387 | 54.629 ± 3.596 | 63.098 ± 6.226 | 41.310 ± 4.125 | 24.705 ± 1.546 |
| Heart to plasma | 18.554 ± 1.699 | 40.049 ± 1.853 | 48.291 ± 4.328 | 31.229 ± 3.950 | 18.638 ± 1.245 |
| 18F-BCPP-BF | |||||
| Brain to blood | 4.432 ± 0.371 | 13.362 ± 1.321 | 12.567 ± 0.708 | 14.817 ± 3.156 | 14.978 ± 3.006 |
| Brain to plasma | 3.926 ± 0.319 | 10.986 ± 1.042 | 10.039 ± 0.786 | 11.658 ± 2.918 | 11.112 ± 2.304 |
| Heart to blood | 19.617 ± 0.680 | 65.826 ± 5.418 | 72.429 ± 1.703 | 76.204 ± 3.909 | 83.791 ± 18.636 |
| Heart to plasma | 17.391 ± 1.020 | 54.127 ± 4.272 | 57.818 ± 2.271 | 59.739 ± 5.148 | 62.153 ± 14.094 |
| 18F-BMS | |||||
| Brain to blood | 5.483 ± 1.289 | 11.318 ± 1.328 | 11.568 ± 2.916 | 6.141 ± 0.399 | 3.169 ± 0.124 |
| Brain to plasma | 4.291 ± 1.030 | 8.804 ± 1.116 | 9.039 ± 2.329 | 4.657 ± 0.128 | 2.511 ± 0.119 |
| Heart to blood | 25.195 ± 4.438 | 56.286 ± 5.319 | 53.204 ± 8.714 | 29.393 ± 2.996 | 14.379 ± 0.442 |
| Heart to plasma | 19.720 ± 3.658 | 43.831 ± 5.400 | 41.555 ± 6.982 | 22.268 ± 1.422 | 11.385 ± 0.172 |
Rats were intravenously injected with 5 MBq of 18F-BCPP-EF, 18F-BCPP-BF, or 18F-BMS via tail vein and sacrificed at 1, 5, 10, 30, and 60 min after injection to obtain tissue samples for uptake ratio analyses. All values are expressed as mean ± SD for 3 animals.