Process | Temperature (°C) | Reaction time (min) | Reagent | Concentration (mM) | Droplet volume (μL) | Fluorination efficiency (%)* | Radioactivity remaining on chip (%)† | Crude radiochemical yield (%)* |
1—Load 18F-TBAF | Room temperature | TBAHCO3 | 22.5 | 6 | Not applicable | Not applicable | ||
2—MeCN azeotropic distillation | 105 | 2 | MeCN | Not applicable | 9 | Not applicable | Not applicable | |
3—Fluorination | 120 | 5 | 18F-FLT precursor | 45 | 4 | 74 ± 6 (n = 8) | 80 (n = 4) | Not applicable |
4—Hydrolysis | 95 | 5 | HCl | 0.75 | 7 | Not applicable | 67 (n = 4) | 49 ± 11 (n = 10) |