Biodistribution of 111In-DOTA-Z09591 at 2 Hours After Injection in BALB/C nu/nu Mice Bearing U-87 MG Xenografts
| Total injected dose (μg) | ||||
| Organ | 0.1 | 0.5 | 1 | 70 |
| Blood | 0.34 ± 0.05 | 0.35 ± 0.07 | 0.26 ± 0.04 | 0.14 ± 0.02 |
| Lung | 0.8 ± 0.2 | 0.72 ± 0.08 | 0.7 ± 0.2 | 0.21 ± 0.02 |
| Liver | 0.99 ± 0.07 *† | 0.84 ± 0.07 | 0.8 ± 0.1 | 0.39 ± 0.05 |
| Spleen | 1.8 ± 0.4 | 2.0 ± 0.3 | 1.6 ± 0.2 | 0.25 ± 0.06 |
| Stomach | 1.1 ± 0.3 | 1.0 ± 0.2 | 0.8 ± 0.2 | 0.19 ± 0.02 |
| Colon | 1.3 ± 0.3 | 1.5 ± 0.2 | 1.1 ± 0.4 | 0.23 ± 0.05 |
| Kidney | 288 ± 15 | 267 ± 40 | 256 ± 19 | 310 ± 32 |
| Tumor | 5.6 ± 1.1 | 6.5 ± 0.9 | 7.2 ± 2.4 | 0.89 ± 0.04 |
| Muscle | 0.4 ± 0.1 | 0.4 ± 0.1 | 0.3 ± 0.1 | 0.07 ± 0.02 |
| Bone | 0.6 ± 0.1 | 0.8 ± 0.2 | 0.6 ± 0.1 | 0.14 ± 0.05 |
| GI tract‡ | 1.2 ± 0.2 | 1.7 ± 0.7 | 1.2 ± 0.2 | 0.50 ± 0.13 |
↵* Significant difference (P < 0.05) between doses 0.1 and 0.5 μg.
↵† Significant difference (P < 0.05) between doses 0.1 and 1 μg.
↵‡ Data for GI tract are presented as %ID per whole sample.
Uptake in all organs and tissues, except kidneys, after injection of 70 μg of 111In-DOTA-Z09591 was significantly lower than after injection of any other dose. Data are presented as average %ID/g and SD for 4 mice.