Tumor-to-Organ Ratios of 111In-DOTA-Z09591 Affibody Molecule (2 Hours After Injection) in BALB/C nu/nu Mice Bearing U-87 MG Xenografts
Dose (μg) | |||
Organ | 0.1 | 0.5 | 1 |
Blood | 17 ± 3 | 19 ± 5 | 28 ± 14 |
Lung | 7 ± 2 | 9 ± 2 | 12 ± 4 |
Liver | 5.6 ± 0.7 | 8 ± 2 | 9 ± 4 |
Spleen | 3.2 ± 0.7 | 3.3 ± 0.5 | 5 ± 2 |
Stomach | 5 ± 1* | 7 ± 2 | 10 ± 3 |
Colon | 4.2 ± 0.7* | 4 ± 1 | 6 ± 1 |
Muscle | 13 ± 3* | 17 ± 7 | 28 ± 7 |
Bone | 8.8 ± 0.8 | 9 ± 3 | 13 ± 4 |
↵* Significant difference (P < 0.05) between doses 0.1 and 1 μg.
Data are presented as average of 4 animals and SD.