TABLE 3

Tumor-to-Organ Ratios of 111In-DOTA-Z09591 Affibody Molecule (2 Hours After Injection) in BALB/C nu/nu Mice Bearing U-87 MG Xenografts

Dose (μg)
Organ0.10.51
Blood17 ± 319 ± 528 ± 14
Lung7 ± 29 ± 212 ± 4
Liver5.6 ± 0.78 ± 29 ± 4
Spleen3.2 ± 0.73.3 ± 0.55 ± 2
Stomach5 ± 1*7 ± 210 ± 3
Colon4.2 ± 0.7*4 ± 16 ± 1
Muscle13 ± 3*17 ± 728 ± 7
Bone8.8 ± 0.89 ± 313 ± 4
  • * Significant difference (P < 0.05) between doses 0.1 and 1 μg.

  • Data are presented as average of 4 animals and SD.