Biodistribution of 111In-DOTA-Z09591 (Injected Dose 1 μg) at 1, 2, and 4 Hours After Injection in BALB/C nu/nu Mice Bearing U-87 MG Xenografts
| Organ | 1 h | 2 h | 4 h |
| Blood | 0.53 ± 0.04*† | 0.35 ± 0.06‡ | 0.20 ± 0.07 |
| Lung | 1.2 ± 0.2† | 0.8 ± 0.3‡ | 0.3 ± 0.1 |
| Liver | 0.90 ± 0.04* | 0.80 ± 0.07 | 0.6 ± 0.2 |
| Spleen | 2.3 ± 0.4† | 1.7 ± 0.3‡ | 1.0 ± 0.2 |
| Stomach | 1.3 ± 0.1*† | 1.0 ± 0.2‡ | 0.5 ± 0.1 |
| Colon | 1.8 ± 0.4† | 1.3 ± 0.2‡ | 0.6 ± 0.2 |
| Kidney | 210 ± 26* | 249 ± 15 | 232 ± 66 |
| Tumor | 5.7 ± 0.6† | 5.9 ± 1.7 | 4.0 ± 0.8 |
| Muscle | 0.61 ± 0.09*† | 0.34 ± 0.03‡ | 0.15 ± 0.05 |
| Bone | 0.79 ± 0.03*† | 0.56 ± 0.06‡ | 0.25 ± 0.03 |
| GI tract§ | 1.9 ± 0.2*† | 1.2 ± 0.2‡ | 0.8 ± 0.2 |
↵* Significant difference (P < 0.05) between 1 and 2 h after injection.
↵† Significant difference (P < 0.05) between 1 and 4 h after injection.
↵‡ Significant difference (P < 0.05) between 2 and 4 h after injection.
↵§ Data for GI tract are presented as %ID per whole sample.
There was no significant difference between data for 2-h time point and data reported for injected dose of 1 μg in Table 1. Data are presented as an average % ID/g and SD for 4 mice.