TABLE 2

Biodistribution Data for ¹¹C-MPDX 80 Minutes After Injection

	SUV for following group:
Tissue	Control (n = 7)	CPA (n = 7)	Caffeine at 4 mg/kg (n = 6)	Caffeine at 40 mg/kg (n = 6)
Amygdala	0.92 ± 0.23	1.29 ± 0.11^*	0.69 ± 0.18	0.52 ± 0.08^*
Olfactory bulbs	0.70 ± 0.24	0.78 ± 0.21	0.58 ± 0.28	0.43 ± 0.13^*
Cerebellum	1.41 ± 0.24	2.23 ± 0.50^*	1.10 ± 0.32	0.69 ± 0.15^*
Cingulate gyrus	1.11 ± 0.27	1.05 ± 0.22	0.60 ± 0.16^*	0.57 ± 0.18^*
Entorhinal cortex	1.23 ± 0.33	1.40 ± 0.20	0.66 ± 0.18^*	0.59 ± 0.16^*
Frontal cortex	1.04 ± 0.26	1.30 ± 0.16^*	0.67 ± 0.17^*	0.51 ± 0.09^*
Hippocampus	1.18 ± 0.25	1.55 ± 0.15^*	0.82 ± 0.30^*	0.57 ± 0.12^*
Medulla	0.90 ± 0.16	1.23 ± 0.28^*	0.70 ± 0.17^*	0.71 ± 0.20
Parietal, temporal, and occipital cortices	1.19 ± 0.30	1.62 ± 0.39^*	0.88 ± 0.24	0.55 ± 0.08^*
Pons	0.89 ± 0.27	1.12 ± 0.30	0.72 ± 0.18	0.64 ± 0.24
Striatum	1.13 ± 0.19	1.40 ± 0.20^*	0.81 ± 0.23^*	0.50 ± 0.07^*
Brain tissue left over after dissection	1.17 ± 0.27	1.53 ± 0.34^*	0.89 ± 0.28	0.59 ± 0.10^*
Bone	0.29 ± 0.14	0.33 ± 0.11	0.32 ± 0.06	0.35 ± 0.05
Colon	0.80 ± 0.30	0.98 ± 0.44	0.90 ± 0.19	1.01 ± 0.22
Duodenum	1.50 ± 0.29	1.63 ± 0.65	1.74 ± 0.56	1.02 ± 0.28^*
Fat	1.78 ± 0.43	1.41 ± 0.30	2.37 ± 1.23	1.99 ± 1.02
Heart	0.80 ± 0.14	0.99 ± 0.18	0.91 ± 0.21	0.86 ± 0.15
Ileum	1.24 ± 0.29	1.26 ± 0.38	1.31 ± 0.45	1.12 ± 0.17
Kidneys	1.31 ± 0.15	1.49 ± 0.24	1.19 ± 0.25	1.45 ± 0.21
Liver	2.69 ± 0.49	3.25 ± 0.33^*	3.09 ± 0.67	2.74 ± 0.48
Lungs	0.86 ± 0.10	0.87 ± 0.09	0.85 ± 0.14	0.95 ± 0.19
Muscle	0.45 ± 0.06	0.53 ± 0.11	0.54 ± 0.09	0.50 ± 0.12
Pancreas	1.24 ± 0.27	1.37 ± 0.25	1.37 ± 0.48	1.51 ± 0.46
Plasma	0.90 ± 0.11	0.78 ± 0.10	0.92 ± 0.16	0.87 ± 0.17
Red cells	0.42 ± 0.06	0.46 ± 0.08	0.41 ± 0.12	0.47 ± 0.09
Spleen	1.22 ± 0.18	1.15 ± 0.20	0.97 ± 0.20^*	0.81 ± 0.18^*
Trachea	0.64 ± 0.18	0.66 ± 0.13	0.84 ± 0.20	1.15 ± 0.20^*
Urine	0.32 ± 0.39	0.03 ± 0.02	1.14 ± 0.73^*	0.40 ± 0.88

↵* Significantly different from control group.
Data are reported as mean ± SD.