TABLE 3

Univariate and Multivariate Analyses of Potential Factors Contributing to OS

	OS (mo)			Multivariate analysis
Factor	Median	95% CI	Univariate analysis^* (P)	Hazard ratio (95% CI)	P
All patients	55	49–61
Age
≤65 y	55	46–64
>65 y	51	38–64	0.526
Tumor type
P-NET	57	48–66
Other GEP NET	43	31–55	0.037		0.173
Performance status
KPS ≤ 70	39	30–48
KPS > 70	57	47–67	0.003	2.7 (1.3–5.5)	0.006
Functionality
Nonfunctional	55	50–60
Functional	43	NA	0.630
CgA
≤600 ng/mL	55	NA
>600 ng/mL	43	32–54	0.052
NSE
≤15 ng/mL	57	45–69
>15 ng/mL	45	40–53	0.032	2.8 (1.3–5.9)	0.006
Ki-67 index
≤10%	55	47–62
>10%	34	25–42	0.001	3.1 (1.4–6.9)	0.004
Hepatic tumor burden^†
<25%	NR	NA
≥25%	43	37–50	0.007	2.1 (1.0–4.5)	0.044
Tracer uptake
≤ Grade 2	55	NA
> Grade 2	55	44–66	0.774

↵* Log-rank test.
↵† Fraction of total liver volume.
P-NET = pancreatic NET; CgA = chromogranin A; NR = not reached; NA = not available because of censored cases.