Protocol for 18F-FDG PET to Detect CS
| Procedure | Goal |
| Preparation | Suppress myocardial glucose utilization |
| Long-term fasting (>12 h), and/or | |
| High-fat, low-carbohydrate meal, and/or | |
| Intravenous nonfractionated heparin (50 units/kg, 15 min before 18F-FDG) | |
| Prolonged uptake period (>90 min) after 18F-FDG injection | |
| Imaging | |
| Stress perfusion imaging (only if needed) | Rule out ischemic heart disease |
| Rest perfusion imaging | Identify myocardial contours to localize 18F-FDG hot spots; detect regional tissue damage |
| Electrocardiographic gating of perfusion study | Identify LV dysfunction |
| Cardiac 18F-FDG imaging | Identify or localize inflammatory hot spots |
| Whole-body 18F-FDG imaging | Identify extracardiac inflammatory lesions |